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Heterogeneity of the tumor immune microenvironment and clinical interventions

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 617-648 doi: 10.1007/s11684-023-1015-9

Abstract: Heterogeneity of the tumor immune microenvironment and clinical interventions

Keywords： Heterogeneity tumor immune    

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Exploring financially constrained small- and medium-sized enterprises based on a multi-relation translational graph attention network Research Article

Qianqiao LIANG, Hua WEI, Yaxi WU, Feng WEI, Deng ZHAO, Jianshan HE, Xiaolin ZHENG, Guofang MA, Bing HAN

Frontiers of Information Technology & Electronic Engineering 2023, Volume 24, Issue 3,   Pages 388-402 doi: 10.1631/FITEE.2200151

Abstract: In this paper, we first perform an insightful exploratory analysis to exploit the transfer phenomenonThe main challenge lies in modeling two kinds of heterogeneity, i.e., and SMEs' , under different relation

Keywords： Financing needs exploration     Graph representation learning     Transfer heterogeneity     Behavior heterogeneity    

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Intratumor heterogeneity, microenvironment, and mechanisms of drug resistance in glioma recurrence and

Zhaoshi Bao, Yongzhi Wang, Qiangwei Wang, Shengyu Fang, Xia Shan, Jiguang Wang, Tao Jiang

Frontiers of Medicine 2021, Volume 15, Issue 4,   Pages 551-561 doi: 10.1007/s11684-020-0760-2

Abstract: Several studies correlated tumor recurrence with tumor heterogeneity and the immune microenvironment.this review, we introduce the different mechanisms involved in glioma progression, including tumor heterogeneity

Keywords： glioma     evolution mechanism     strategies     tumor heterogeneity     secondary glioma    

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Heterogeneity of chronic obstructive pulmonary disease: from phenotype to genotype

Xu Chen, Xiaomao Xu, Fei Xiao

Frontiers of Medicine 2013, Volume 7, Issue 4,   Pages 425-432 doi: 10.1007/s11684-013-0295-x

Abstract: This review briefly describes the heterogeneity of COPD, with focus on recent advances in the correlations

Keywords： chronic obstructive pulmonary disease     heterogeneity     phenotype     genotype     prediction    

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Computational modeling of fracture in concrete: A review

Luthfi Muhammad Mauludin, Chahmi Oucif

Frontiers of Structural and Civil Engineering 2020, Volume 14, Issue 3,   Pages 586-598 doi: 10.1007/s11709-020-0573-z

Abstract: As heterogeneity of concrete material is major concern in micromechanical-based concrete modeling, one

Keywords： concrete fracture     macroscopic     micromechanical     heterogeneity    

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Analysis of stress and failure in rock specimens with closed and open flaws on the surface

Frontiers of Structural and Civil Engineering 2021, Volume 15, Issue 5,   Pages 1222-1237 doi: 10.1007/s11709-021-0773-1

Abstract: The influence of closed and open surface flaws on the stress distribution and failure in rock specimens is investigated. Heterogeneous finite element models are developed to simulate the compression tests on flawed rock specimens. The simulated specimens include those with closed flaws and those with open flaws on the surface. Systematic analyses are conducted to investigate the influences of the flaw inclination, friction coefficient and the confining stress on failure behavior. Numerical results show significant differences in the stress, displacement, and failure behavior of the closed and open flaws when they are subjected to pure compression; however, their behaviors under shear and tensile loads are similar. According to the results, when compression is the dominant mode of stress applied to the flaw surface, an open flaw may play a destressing role in the rock and relocate the stress concentration and failure zones. The presented results in this article suggest that failure at the rock surface may be managed in a favorable manner by fabricating open flaws on the rock surface. The insights gained from this research can be helpful in managing failure at the boundaries of rock structures.

Keywords： surface flaw     heterogeneity     circular hole     numerical modeling     relative displacement    

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A multiscale material model for heterogeneous liquid droplets in solid soft composites

Frontiers of Structural and Civil Engineering 2021, Volume 15, Issue 5,   Pages 1292-1299 doi: 10.1007/s11709-021-0771-3

Abstract: Liquid droplets in solid soft composites have been attracting increasing attention in biological applications. In contrary with conventional composites, which are made of solid elastic inclusions, available material models for composites including liquid droplets are for highly idealized configurations and do not include all material real parameters. They are also all deterministic and do not address the uncertainties arising from droplet radius, volume fraction, dispersion and agglomeration. This research revisits the available models for liquid droplets in solid soft composites and presents a multiscale computational material model to determine their elastic moduli, considering nearly all relevant uncertainties and heterogeneities at different length scales. The effects of surface tension at droplets interface, their volume fraction, size, size polydispersity and agglomeration on elastic modulus, are considered. Different micromechanical material models are incorporated into the presented computational framework. The results clearly indicate both softening and stiffening effects of liquid droplets and show that the model can precisely predict the effective properties of liquid droplets in solid soft composites.

Keywords： liquid in solid     soft composite     computational modeling     multiscale model     heterogeneity    

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Heterogeneous influence of individuals’ behavior on mask efficacy in gathering environments

Frontiers of Engineering Management   Pages 550-562 doi: 10.1007/s42524-022-0193-5

Abstract: The heterogeneity of individuals can cause mask efficacy in a specific gathering environment to be differentFurthermore, the heterogeneity of gathering environments causes the epidemic prevention effect of masksGiven the heterogeneity of individual behavior, if individuals who are more active in terms of interpersonal

Keywords： COVID-19     masks     behavioral heterogeneity     asymptomatic infection    

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Factors affecting the distribution of microplastics in soils of China

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 9, doi: 10.1007/s11783-023-1710-4

Abstract:

● Microplastic (MP) abundance in soil of China was highly heterogeneous.

Keywords： Microplastic distribution     Microplastic heterogeneity     Effecting factors     Agriculture     Socio-economic    

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Temporal and spatial stability of the EM/PM molecular subtypes in adult diffuse glioma

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 240-262 doi: 10.1007/s11684-022-0936-z

Abstract: Detailed characterizations of genomic alterations have not identified subtype-specific vulnerabilities in adult gliomas. Mapping gliomas into developmental programs may uncover new vulnerabilities that are not strictly related to genomic alterations. After identifying conserved gene modules co-expressed with EGFR or PDGFRA (EM or PM), we recently proposed an EM/PM classification scheme for adult gliomas in a histological subtype- and grade-independent manner. By using cohorts of bulk samples, paired primary and recurrent samples, multi-region samples from the same glioma, single-cell RNA-seq samples, and clinical samples, we here demonstrate the temporal and spatial stability of the EM and PM subtypes. The EM and PM subtypes, which progress in a subtype-specific mode, are robustly maintained in paired longitudinal samples. Elevated activities of cell proliferation, genomic instability and microenvironment, rather than subtype switching, mark recurrent gliomas. Within individual gliomas, the EM/PM subtype was preserved across regions and single cells. Malignant cells in the EM and PM gliomas were correlated to neural stem cell and oligodendrocyte progenitor cell compartment, respectively. Thus, while genetic makeup may change during progression and/or within different tumor areas, adult gliomas evolve within a neurodevelopmental framework of the EM and PM molecular subtypes. The dysregulated developmental pathways embedded in these molecular subtypes may contain subtype-specific vulnerabilities.

Keywords： glioma progression     molecular classification     EM/PM subtyping     intratumor heterogeneity    

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Augmentation of natural convective heat transfer by acoustic cavitation

Jun CAI, Xiulan HUAI, Shiqiang LIANG, Xunfeng LI,

Frontiers in Energy 2010, Volume 4, Issue 3,   Pages 313-318 doi: 10.1007/s11708-009-0064-3

Abstract: experimental study was conducted to investigate the effects of acoustic cavitation on natural convective heat transferThe experimental results indicated that heat transfer could be enhanced by acoustic cavitation and had

Keywords： heat transfer enhancement     augmentation     acoustic cavitation     acoustic streaming     convective heat transfer    

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Experimental study of heat transfer coefficient with rectangular baffle fin of solar air heater

Foued CHABANE,Nesrine HATRAF,Noureddine MOUMMI

Frontiers in Energy 2014, Volume 8, Issue 2,   Pages 160-172 doi: 10.1007/s11708-014-0321-y

Abstract: The heat transfer coefficient between the absorber plate and air can be considerably increased by usingexperimental study has been conducted to investigate the effect of roughness and operating parameters on heat transferTo determine the enhancement in heat transfer and increment in thermal efficiency, the values of Nusselt

Keywords： Nusselt number     flow rate     heat transfer     heat transfer coefficient     thermal efficiency     forced convection    

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Effect of heat transfer space non-uniformity of combustion chamber components on in-cylinder heat transfer

Jizu LV, Minli BAI, Long ZHOU, Jian ZHOU,

Frontiers in Energy 2010, Volume 4, Issue 3,   Pages 392-401 doi: 10.1007/s11708-009-0066-1

Abstract: Based on the three-dimensional numerical simulation of the heat transfer of the coupled body, a coupledThe model was applied in the investigation of the influence of space non-uniformity in heat transferamong combustion chamber components on in-cylinder heat transfer.effect of wall temperature space non-uniform distribution of combustion chamber components on heat transferwall temperature space non-uniform distribution of combustion chamber components would influence heat transfer

Keywords： heat transfer     space non-uniformity     soot emission     in-cylinder     diesel    

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Heat transfer coefficient of wheel rim of large capacity steam turbines

SHI Jinyuan, DENG Zhicheng, YANG Yu, JUN Ganwen

Frontiers in Energy 2008, Volume 2, Issue 1,   Pages 20-24 doi: 10.1007/s11708-008-0015-4

Abstract: A way of calculating the overall equivalent heat transfer coefficient of wheel rims of large capacityThe method and formula to calculate the mean forced convection heat-transfer coefficient of the surfaceA fin heat transfer model was then used to calculate the equivalent heat transfer coefficient of theThe overall equivalent heat transfer coefficient of the wheel rim was then calculated using a cylindricalThe proposed method helps determine the heat transfer boundary conditions in finite element analyses

Keywords： convection heat-transfer     capacity     heat-transfer coefficient     bottom     transmission    

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Numerical simulation of damage in high arch dam due to earthquake

Hong ZHONG , Gao LIN , Hongjun LI

Frontiers of Structural and Civil Engineering 2009, Volume 3, Issue 3,   Pages 316-322 doi: 10.1007/s11709-009-0039-9

Abstract: the cracking evolution process and damage mode of high arch dams are studied in consideration of the heterogeneity

Keywords： mesoscopic heterogeneity     damage simulation in earthquakes     arch dam    

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Title Author Date Type Operation

Heterogeneity of the tumor immune microenvironment and clinical interventions

Journal Article

Exploring financially constrained small- and medium-sized enterprises based on a multi-relation translational graph attention network

Qianqiao LIANG, Hua WEI, Yaxi WU, Feng WEI, Deng ZHAO, Jianshan HE, Xiaolin ZHENG, Guofang MA, Bing HAN

Journal Article

Intratumor heterogeneity, microenvironment, and mechanisms of drug resistance in glioma recurrence and

Zhaoshi Bao, Yongzhi Wang, Qiangwei Wang, Shengyu Fang, Xia Shan, Jiguang Wang, Tao Jiang

Journal Article

Heterogeneity of chronic obstructive pulmonary disease: from phenotype to genotype

Xu Chen, Xiaomao Xu, Fei Xiao

Journal Article

Computational modeling of fracture in concrete: A review

Luthfi Muhammad Mauludin, Chahmi Oucif

Journal Article

Analysis of stress and failure in rock specimens with closed and open flaws on the surface

Journal Article

A multiscale material model for heterogeneous liquid droplets in solid soft composites

Journal Article

Heterogeneous influence of individuals’ behavior on mask efficacy in gathering environments

Journal Article

Factors affecting the distribution of microplastics in soils of China

Journal Article

Temporal and spatial stability of the EM/PM molecular subtypes in adult diffuse glioma

Journal Article

Augmentation of natural convective heat transfer by acoustic cavitation

Jun CAI, Xiulan HUAI, Shiqiang LIANG, Xunfeng LI,

Journal Article

Experimental study of heat transfer coefficient with rectangular baffle fin of solar air heater

Foued CHABANE,Nesrine HATRAF,Noureddine MOUMMI

Journal Article

Effect of heat transfer space non-uniformity of combustion chamber components on in-cylinder heat transfer

Jizu LV, Minli BAI, Long ZHOU, Jian ZHOU,

Journal Article

Heat transfer coefficient of wheel rim of large capacity steam turbines

SHI Jinyuan, DENG Zhicheng, YANG Yu, JUN Ganwen

Journal Article

Numerical simulation of damage in high arch dam due to earthquake

Hong ZHONG , Gao LIN , Hongjun LI

Journal Article